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Home - Products - Metabolic Enzyme/Protease - Phosphatase - PTP Inhibitor IV

PTP Inhibitor IV

CAS No. 329317-98-8

PTP Inhibitor IV( —— )

Catalog No. M33787 CAS No. 329317-98-8

PTP Inhibitor IV is an effective protein tyrosine phosphatase (PTP) inhibitor, which can selectively inhibit DUSP14 phosphatase activity (IC50.5.21μm).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PTP Inhibitor IV
  • Note
    Research use only, not for human use.
  • Brief Description
    PTP Inhibitor IV is an effective protein tyrosine phosphatase (PTP) inhibitor, which can selectively inhibit DUSP14 phosphatase activity (IC50.5.21μm).
  • Description
    PTP Inhibitor IV is a protein tyrosine phosphatase (PTP) inhibitor that competitively inhibits DUSP14 phosphatase activity with an 50 of 5.21 μM. PTP Inhibitor IV inhibits SHP-2, PTP1B, PTP-ε, PTP Meg-2, PTP-σ, PTP-β, and PTP-μ with 50s of 1.8 μM, 2.5 μM, 8.4 μM, 13 μM, 20 μM, 6.4 μM, and 6.7 μM, respectively.
  • In Vitro
    Western Blot Analysis Cell Line:HEK 293 cells Concentration:0, 10 μM, 50 μM, or 100 μM Incubation Time:3 hours Result: Effectively penetrated the cells and inhibited DUSP14 activity.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Phosphatase
  • Recptor
    Phosphatase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    329317-98-8
  • Formula Weight
    608.62
  • Molecular Formula
    C26H26F6N2O4S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (410.77 mM; Ultrasonic )
  • SMILES
    C(C)(C)(C1=CC=C(C(C)(C)C2=CC=C(NS(C(F)(F)F)(=O)=O)C=C2)C=C1)C3=CC=C(NS(C(F)(F)F)(=O)=O)C=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jae Eun Park, et al. PTP inhibitor IV protects JNK kinase activity by inhibiting dual-specificity phosphatase 14 (DUSP14). Biochem Biophys Res Commun. 2009 Oct 2;387(4):795-9. ?
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